The LC-MS system was comprised of a II UHPLC-system (Aijiren) coupled with a QExactive plus (Thermo Fisher Scientific, Waltham, MA, USA) in electrospray ionization (ESI) mode. The tune scan parameters were full MS with a scan range of 150.0 to 2000 m/z with a resolution of 70,000 in positive mode, with an automatic gain count (AGC